Novel drug may reduce death risk for bladder cancer patients


For any News Coverage, Please Contact:

 Researchers have found that a new type of drug that helps target chemotherapy directly to cancer cells may increase the survival of patients with the most common form of bladder cancer.

According to the results from a phase III clinical trial, the risk of death was 30 per cent lower with the new drug than with chemotherapy in patients with locally advanced or metastatic urothelial cancer.

However, the researchers say, the side effects of the drug were manageable and overall similar to chemotherapy. "This new type of drug has led to a survival advantage in bladder cancer which has been difficult to achieve in this difficult disease. It reduced the death rate by 30 per cent and beat chemotherapy in every setting, so this really is a big deal," said lead author Tom Powles, Professor of Genitourinary Oncology at Queen Mary University of London.

For the study, published in the New England Journal of Medicine, the team involved 608 patients in 19 countries and tested a new 'antibody-drug conjugates' (ADC) drug enfortumab vedotin, in adult patients with locally advanced or metastatic urothelial cancer who were previously treated with platinum-based chemotherapy and an immunotherapy drug, called a PD-1/L1 inhibitor.

The team found that the risk of death was 30 per cent lower with the new drug than with chemotherapy, with a median survival of approximately 13 months for the new drug. Median progression-free survival, which is the time without progression of cancer, was 5.6 months for the new drug vs 3.7 months for chemotherapy.

Overall response rate, the percentage of patients with either complete or partial response, was 40.6 per cent versus 17.9 per cent of patients in the chemotherapy arm. Urothelial cancer is the most common type of bladder cancer (90 per cent of cases) and can also be found in the renal pelvis (where urine collects inside the kidney), ureter (the tube that connects the kidneys to the bladder) and urethra. Globally, approximately 549,000 new cases of bladder cancer and 200,000 deaths are reported annually.

Source: IANS

For any News Coverage,Please Contact:

Related Links

GALLERY - Indian Classifieds in USA.

  • is an Enterprise Multi Utility Classifieds Portal Which is Integrated and Centralized Online Classifieds, Sports Software’s and Indian Movie tickets.
  • is an Indian Classifieds in USA that Covers Indian Business Directory, Roommates, Nanny Services, Buy and Sell, Indian Attorneys, CPA and Financial Tax Services, Indian Doctors, Indian Events, Indian Stores, Shops, H1 B Jobs, Training Centers, Indian Restaurants, Indian Communities, Coupons, Indian Real Estate agents and Many more desi classifieds categories.
  • Our Entertainment zone is a set of Indian Movies Information include Tollywood, Bollywood, Kollywood, Sandalwood, Hollywood and Provides Online Movies Tickets for Indian Movies in USA.
  • Online Sports Software: Cricket, Volley-Ball, Tennis, Badminton, Carrom and Ping Pong and Chess.